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CMap Candidate Details

Structure:
CMap ID: C02970
Pert ID: BRD-A67516570
Compound Name: lafutidine
Targets: HRH2
MoA: histamine receptor antagonist
SMILES: O=C(CS(=O)Cc1ccco1)NC\C=C/COc1cc(CN2CCCCC2)ccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124950 BRD-A67516570 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124989 BRD-A67516570 A549 0.125 uM 24 h -0.23 -0.97 0.1 0.21 0.76 0.05
125013 BRD-A67516570 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
125090 BRD-A67516570 MCF10A 0.04 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
125127 BRD-A67516570 MDAMB231 0.04 uM 24 h 0.21 0.86 0.01 -0.31 -1.05 0.71
125192 BRD-A67516570 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125227 BRD-A67516570 YAPC 1.11 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
133081 BRD-A67516570 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133107 BRD-A67516570 HELA 0.08 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
133136 BRD-A67516570 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133250 BRD-A67516570 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133308 BRD-A67516570 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).