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CMap Candidate Details

Structure:
CMap ID: C02980
Pert ID: BRD-K48894757
Compound Name: laropiprant
Targets: PTGDR|PTGDR2|PTGER1|PTGER2|PTGER3|PTGFR|PTGIR|TBXA2R
MoA: prostanoid receptor antagonist
SMILES: CS(=O)(=O)c1cc(F)cc2c3CC[C@H](CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125242 BRD-K48894757 A375 10 uM 24 h -0.16 -0.68 0.0 0.0 0.0 0.0
125322 BRD-K48894757 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125378 BRD-K48894757 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
125403 BRD-K48894757 JURKAT 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
125451 BRD-K48894757 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125498 BRD-K48894757 PC3 10 uM 24 h -0.22 -0.93 0.07 0.41 1.46 2.23
125525 BRD-K48894757 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133368 BRD-K48894757 A549 0.25 uM 24 h 0.22 0.91 0.04 -0.34 -1.13 0.98
133394 BRD-K48894757 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133428 BRD-K48894757 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133523 BRD-K48894757 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133560 BRD-K48894757 MDAMB231 0.08 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
133637 BRD-K48894757 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).