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CMap Candidate Details

Structure:
CMap ID: C03010
Pert ID: BRD-K75024268
Compound Name: lesinurad
Targets: SLC22A12
MoA: uric acid diuretic
SMILES: OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121723 BRD-K75024268 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.55
121769 BRD-K75024268 HELA 0.37 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
121798 BRD-K75024268 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129797 BRD-K75024268 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129836 BRD-K75024268 HEK293 0.25 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
129962 BRD-K75024268 MCF10A 0.03 uM 24 h -0.26 -1.09 0.33 0.24 0.85 0.15
130005 BRD-K75024268 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
130047 BRD-K75024268 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130086 BRD-K75024268 PC3 0.03 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
130118 BRD-K75024268 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130164 BRD-K75024268 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).