CMap Candidate Details
Structure:
| CMap ID: | C03044 |
| Pert ID: | BRD-K03095347 |
| Compound Name: | levosimendan |
| Targets: | KCNJ11|KCNJ8|PDE3A|TNNC1 |
| MoA: | calcium sensitizer |
| SMILES: | C[C@@H]1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122841 | BRD-K03095347 | A375 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122916 | BRD-K03095347 | HEK293 | 10 uM | 24 h | 0.31 | 1.29 | 0.66 | -0.2 | -0.66 | 0.01 |
| 122990 | BRD-K03095347 | HT29 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123041 | BRD-K03095347 | JURKAT | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123082 | BRD-K03095347 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123131 | BRD-K03095347 | MDAMB231 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123203 | BRD-K03095347 | THP1 | 10 uM | 24 h | 0.22 | 0.91 | 0.04 | -0.37 | -1.26 | 1.36 |
| 131259 | BRD-K03095347 | A549 | 0.01 uM | 24 h | -0.22 | -0.93 | 0.07 | 0.0 | 0.0 | 0.0 |
| 131291 | BRD-K03095347 | HA1E | 0.08 uM | 24 h | 0.23 | 0.98 | 0.09 | 0.0 | 0.0 | 0.0 |
| 131315 | BRD-K03095347 | HELA | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131378 | BRD-K03095347 | HUVEC | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.04 | 0.67 |
| 131414 | BRD-K03095347 | MCF10A | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131472 | BRD-K03095347 | PC3 | 0.03 uM | 24 h | 0.21 | 0.89 | 0.02 | 0.0 | 0.0 | 0.0 |
| 131511 | BRD-K03095347 | YAPC | 0.01 uM | 24 h | 0.28 | 1.16 | 0.35 | -0.33 | -1.12 | 0.93 |