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CMap Candidate Details

Structure:
CMap ID: C00305
Pert ID: BRD-K91290917
Compound Name: amodiaquine
Targets: HNMT
MoA: histamine receptor agonist
SMILES: CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5695 BRD-K91290917 HCC515 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
5963 BRD-K91290917 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6600 BRD-K91290917 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39367 BRD-K91290917 A549 10 uM 24 h -0.26 -1.1 0.35 -0.28 -0.93 0.34
39822 BRD-K91290917 ASC 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
41245 BRD-K91290917 NPC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
41586 BRD-K91290917 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96743 BRD-K91290917 A375 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
121737 BRD-K91290917 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121768 BRD-K91290917 HELA 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
121797 BRD-K91290917 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121819 BRD-K91290917 MCF??7.00 10 uM 24 h -0.16 -0.67 0.0 0.0 0.0 0.0
121845 BRD-K91290917 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
129834 BRD-K91290917 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129920 BRD-K91290917 JURKAT 0.01 uM 24 h -0.19 -0.79 0.0 0.34 1.19 1.01
129960 BRD-K91290917 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
130045 BRD-K91290917 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130116 BRD-K91290917 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130162 BRD-K91290917 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).