CMap Candidate Details
Structure:
| CMap ID: | C03100 |
| Pert ID: | BRD-K27955832 |
| Compound Name: | lomeguatrib |
| Targets: | MGMT |
| MoA: | O6-alkylguanine-DNA alkyltransferase inhibitor |
| SMILES: | Nc1nc(OCc2cc(Br)cs2)c2[nH]cnc2n1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 118495 | BRD-K27955832 | HCC515 | 10 uM | 24 h | 0.29 | 1.21 | 0.46 | 0.0 | 0.0 | 0.0 |
| 118541 | BRD-K27955832 | HEPG2 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.21 | 0.74 | 0.04 |
| 118581 | BRD-K27955832 | HT29 | 10 uM | 24 h | 0.25 | 1.05 | 0.16 | 0.28 | 0.99 | 0.39 |
| 118618 | BRD-K27955832 | MCF??7.00 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 119941 | BRD-K27955832 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.2 | 1.21 |
| 119983 | BRD-K27955832 | A549 | 0.04 uM | 24 h | 0.21 | 0.88 | 0.02 | 0.0 | 0.0 | 0.0 |
| 120022 | BRD-K27955832 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120070 | BRD-K27955832 | HELA | 10 uM | 3 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.06 | 0.73 |
| 120180 | BRD-K27955832 | PC3 | 10 uM | 24 h | -0.18 | -0.76 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128868 | BRD-K27955832 | YAPC | 0.08 uM | 24 h | -0.21 | -0.88 | 0.03 | 0.0 | 0.0 | 0.0 |