CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03101
Pert ID:	BRD-K62858456
Compound Name:	lomerizine
Targets:	CACNA1B\|SCN5A
MoA:	calcium channel blocker
SMILES:	COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1160	BRD-K62858456	MCF??7.00	10 uM	24 h	0.21	0.88	0.02	0.3	1.05	0.57
1187	BRD-K62858456	PC3	10 uM	24 h	-0.24	-1.0	0.15	0.0	0.0	0.0
1259	BRD-K62858456	A549	10 uM	48 h	0.0	0.0	0.0	0.28	1.01	0.44
1336	BRD-K62858456	U2OS	10 uM	24 h	-0.27	-1.11	0.37	0.0	0.0	0.0
25402	BRD-K62858456	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91210	BRD-K62858456	HUH7	6.66 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
124574	BRD-K62858456	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124611	BRD-K62858456	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124655	BRD-K62858456	HELA	0.04 uM	24 h	-0.2	-0.82	0.0	0.26	0.93	0.28
124687	BRD-K62858456	HT29	0.125 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
124720	BRD-K62858456	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124740	BRD-K62858456	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124790	BRD-K62858456	MDAMB231	3.33 uM	24 h	0.29	1.2	0.42	0.0	0.0	0.0
124873	BRD-K62858456	THP1	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.52
124911	BRD-K62858456	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132747	BRD-K62858456	HEK293	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary