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CMap Candidate Details

Structure:
CMap ID: C03106
Pert ID: BRD-K78513633
Compound Name: lonidamine
Targets: GCK
MoA: glucokinase inhibitor
SMILES: OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8986 BRD-K78513633 A375 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9232 BRD-K78513633 A549 200 uM 6 h -0.28 -1.16 0.46 0.0 0.0 0.0
9509 BRD-K78513633 AGS 200 uM 6 h -0.23 -0.95 0.09 0.36 1.28 1.35
9814 BRD-K78513633 H1299 200 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.3
9925 BRD-K78513633 HA1E 200 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
10304 BRD-K78513633 HCC515 200 uM 6 h 0.27 1.12 0.26 -0.29 -0.96 0.44
10596 BRD-K78513633 HCT116 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10849 BRD-K78513633 HEPG2 200 uM 6 h 0.0 0.0 0.0 0.25 0.89 0.2
11180 BRD-K78513633 MCF??7.00 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11575 BRD-K78513633 NCIH2073 200 uM 6 h -0.23 -0.98 0.12 0.0 0.0 0.0
11839 BRD-K78513633 NCIH508 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12133 BRD-K78513633 NCIH596 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12382 BRD-K78513633 NOMO1 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12496 BRD-K78513633 PC3 200 uM 24 h 0.22 0.9 0.02 -0.21 -0.72 0.04
12870 BRD-K78513633 SW480 200 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.68
13682 BRD-K78513633 VCAP 200 uM 6 h -0.22 -0.9 0.04 -0.25 -0.84 0.17
127120 BRD-K78513633 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127154 BRD-K78513633 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127294 BRD-K78513633 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127329 BRD-K78513633 YAPC 3.33 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
135118 BRD-K78513633 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
135188 BRD-K78513633 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
135220 BRD-K78513633 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
135287 BRD-K78513633 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).