CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03111
Pert ID:	BRD-A11990600
Compound Name:	lorazepam
Targets:	GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|TSPO
MoA:	benzodiazepine receptor agonist
SMILES:	OC1N=C(c2ccccc2Cl)c2cc(Cl)ccc2NC1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1142	BRD-A11990600	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
1310	BRD-A11990600	MCF??7.00	0.12 uM	6 h	0.0	0.0	0.0	-0.35	-1.17	1.14
1366	BRD-A11990600	U2OS	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
1420	BRD-A11990600	NPC	25 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
25122	BRD-A11990600	PC3	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
25466	BRD-A11990600	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
122233	BRD-A11990600	A375	10 uM	24 h	-0.22	-0.93	0.07	-0.38	-1.29	1.53
122455	BRD-A11990600	THP1	10 uM	24 h	0.28	1.19	0.41	0.0	0.0	0.0
122505	BRD-A11990600	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130578	BRD-A11990600	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130608	BRD-A11990600	HEK293	0.08 uM	24 h	-0.33	-1.37	1.08	0.0	0.0	0.0
130649	BRD-A11990600	HELA	0.74 uM	24 h	0.29	1.23	0.5	0.0	0.0	0.0
130689	BRD-A11990600	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130730	BRD-A11990600	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130774	BRD-A11990600	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary