CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03119
Pert ID:	BRD-K56195681
Compound Name:	losmapimod
Targets:	MAPK14
MoA:	p38 MAPK inhibitor
SMILES:	Cc1c(F)cc(cc1-c1ccc(cn1)C(=O)NCC(C)(C)C)C(=O)NC1CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95323	BRD-K56195681	A549	10 uM	48 h	0.0	0.0	0.0	-0.28	-0.94	0.37
95375	BRD-K56195681	MCF??7.00	10 uM	6 h	-0.26	-1.06	0.26	0.2	0.7	0.01
95405	BRD-K56195681	U2OS	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.15
95827	BRD-K56195681	A375	0.25 uM	6 h	0.0	0.0	0.0	0.25	0.89	0.21
95857	BRD-K56195681	NPC	0.25 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123867	BRD-K56195681	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.76	0.07
123889	BRD-K56195681	HEK293	10 uM	24 h	0.0	0.0	0.0	0.31	1.09	0.67
123988	BRD-K56195681	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124044	BRD-K56195681	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
124117	BRD-K56195681	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124171	BRD-K56195681	THP1	1.11 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
124224	BRD-K56195681	YAPC	3.33 uM	24 h	-0.2	-0.83	0.0	0.0	0.0	0.0
132188	BRD-K56195681	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.27	0.96	0.33
132221	BRD-K56195681	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132290	BRD-K56195681	PC3	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary