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CMap Candidate Details

Structure:
CMap ID: C03121
Pert ID: BRD-K09416995
Compound Name: lovastatin
Targets: HDAC2|HMGCR|ITGAL|NR1I2
MoA: HMGCR inhibitor
SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4055 BRD-K09416995 HA1E 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
4357 BRD-K09416995 HCC515 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
4644 BRD-K09416995 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
19410 BRD-K09416995 A549 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.2
20250 BRD-K09416995 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20577 BRD-K09416995 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
21708 BRD-K09416995 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.71
37119 BRD-K09416995 A375 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
37588 BRD-K09416995 ASC 10 uM 24 h -0.24 -1.01 0.16 0.21 0.76 0.05
38181 BRD-K09416995 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
38423 BRD-K09416995 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90713 BRD-K09416995 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91123 BRD-K09416995 HUH7 8 uM 72 h 0.0 0.0 0.0 -0.28 -0.94 0.36
98335 BRD-K09416995 NEU 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.14
100048 BRD-K09416995 U2OS 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).