CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03125
Pert ID:	BRD-A43082555
Compound Name:	loxoprofen
Targets:	PTGS2
MoA:	cyclooxygenase inhibitor; prostanoid receptor antagonist
SMILES:	CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25295	BRD-A43082555	VCAP	10 uM	24 h	0.0	0.0	0.0	0.34	1.19	1.03
123280	BRD-A43082555	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123375	BRD-A43082555	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123436	BRD-A43082555	PC3	0.04 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.6
123507	BRD-A43082555	YAPC	3.33 uM	24 h	-0.22	-0.94	0.07	-0.32	-1.08	0.79
131533	BRD-A43082555	A375	0.08 uM	24 h	0.19	0.79	0.0	0.34	1.22	1.15
131562	BRD-A43082555	A549	2.22 uM	24 h	0.2	0.85	0.01	-0.24	-0.81	0.14
131642	BRD-A43082555	HEK293	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131670	BRD-A43082555	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131692	BRD-A43082555	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131798	BRD-A43082555	JURKAT	0.08 uM	24 h	0.0	0.0	0.0	-0.36	-1.2	1.21
131871	BRD-A43082555	MCF??7.00	0.03 uM	24 h	0.21	0.88	0.01	-0.25	-0.85	0.2
131903	BRD-A43082555	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131940	BRD-A43082555	THP1	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary