CMap Candidate Details
Structure:
| CMap ID: | C03137 |
| Pert ID: | BRD-K69236721 |
| Compound Name: | lumacaftor |
| Targets: | CFTR |
| MoA: | CFTR channel agonist |
| SMILES: | Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 126358 | BRD-K69236721 | A375 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.24 | 1.32 |
| 126375 | BRD-K69236721 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.23 | 0.8 | 0.08 |
| 126399 | BRD-K69236721 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.18 | 1.14 |
| 126427 | BRD-K69236721 | HEK293 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126574 | BRD-K69236721 | PC3 | 10 uM | 24 h | 0.26 | 1.08 | 0.21 | 0.31 | 1.11 | 0.72 |
| 134424 | BRD-K69236721 | HELA | 0.25 uM | 24 h | -0.24 | -1.0 | 0.15 | -0.31 | -1.06 | 0.73 |
| 134456 | BRD-K69236721 | HT29 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |
| 134493 | BRD-K69236721 | HUVEC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |
| 134534 | BRD-K69236721 | MCF10A | 0.74 uM | 24 h | 0.3 | 1.23 | 0.5 | 0.34 | 1.19 | 1.05 |
| 134564 | BRD-K69236721 | MCF??7.00 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.97 | 0.45 |
| 134593 | BRD-K69236721 | MDAMB231 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134649 | BRD-K69236721 | YAPC | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |