CMap Candidate Details
Structure:
| CMap ID: | C03180 |
| Pert ID: | BRD-K17953908 |
| Compound Name: | LY2886721 |
| Targets: | BACE1 |
| MoA: | beta-secretase inhibitor |
| SMILES: | NC1=N[C@]2(COC[C@@H]2CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95502 | BRD-K17953908 | A549 | 1.11 uM | 48 h | 0.3 | 1.26 | 0.56 | 0.0 | 0.0 | 0.0 |
| 95694 | BRD-K17953908 | U2OS | 1.11 uM | 6 h | -0.18 | -0.74 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120254 | BRD-K17953908 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120421 | BRD-K17953908 | MCF??7.00 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120499 | BRD-K17953908 | YAPC | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.91 | 0.3 |
| 128914 | BRD-K17953908 | HA1E | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128932 | BRD-K17953908 | HELA | 0.74 uM | 3 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128960 | BRD-K17953908 | HT29 | 0.25 uM | 24 h | 0.25 | 1.04 | 0.16 | 0.29 | 1.03 | 0.51 |
| 128979 | BRD-K17953908 | PC3 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |