CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03181
Pert ID:	BRD-K27305650
Compound Name:	LY294002
Targets:	AKT1\|CHEK1\|GSK3B\|LCK\|MAPK1\|MAPK11\|MAPK12\|MAPK14\|MAPK8\|MTOR\|PIK3CA\|PIK3CB\|PIK3CD\|PIK3CG\|PLK1\|PRKCA\|PRKDC\|ROCK1\|RPS6KB1\|SGK1
MoA:	mTOR inhibitor; PI3K inhibitor; DNA dependent protein kinase inhibitor; phosphodiesterase inhibitor; PLK inhibitor
SMILES:	O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1239	BRD-K27305650	A549	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
6736	BRD-K27305650	A375	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.24
7435	BRD-K27305650	HA1E	10 uM	6 h	0.0	0.0	0.0	0.25	0.9	0.21
7641	BRD-K27305650	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
7990	BRD-K27305650	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
59561	BRD-K27305650	VCAP	10 uM	6 h	0.18	0.77	0.0	-0.35	-1.18	1.14
82021	BRD-K27305650	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
88621	BRD-K27305650	PC3	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
95746	BRD-K27305650	NPC	10 uM	6 h	0.0	0.0	0.0	-0.34	-1.14	1.05
95915	BRD-K27305650	YAPC	10 uM	6 h	0.21	0.86	0.01	0.0	0.0	0.0
96066	BRD-K27305650	PHH	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97282	BRD-K27305650	HAP1	3.33 uM	24 h	0.24	1.0	0.11	-0.28	-0.93	0.34
97447	BRD-K27305650	NKDBA	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.57
97810	BRD-K27305650	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.64
110145	BRD-K27305650	U2OS	20 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary