CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03216
Pert ID:	BRD-K25433859
Compound Name:	maprotiline
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HTR2A\|HTR2C\|HTR7\|SLC6A2
MoA:	norepinephrine reputake inhibitor; tricyclic antidepressant
SMILES:	CNCCCC12CCC(c3ccccc13)c1ccccc21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2856	BRD-K25433859	HA1E	10 uM	24 h	0.22	0.91	0.03	0.0	0.0	0.0
3167	BRD-K25433859	HCC515	10 uM	24 h	-0.28	-1.17	0.49	0.31	1.09	0.67
3757	BRD-K25433859	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24567	BRD-K25433859	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25013	BRD-K25433859	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44904	BRD-K25433859	ASC	10 uM	24 h	-0.24	-0.99	0.13	0.0	0.0	0.0
45208	BRD-K25433859	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.31	1.11	0.73
45474	BRD-K25433859	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
46023	BRD-K25433859	NPC	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.48
46341	BRD-K25433859	PHH	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.64
46657	BRD-K25433859	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99775	BRD-K25433859	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
120974	BRD-K25433859	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121005	BRD-K25433859	HELA	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
121131	BRD-K25433859	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129103	BRD-K25433859	A375	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129233	BRD-K25433859	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary