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CMap Candidate Details

Structure:
CMap ID: C03222
Pert ID: BRD-K71035033
Compound Name: masitinib
Targets: FGFR3|KIT|PDGFRA|PDGFRB
MoA: KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; src inhibitor
SMILES: CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1159 BRD-K71035033 MCF??7.00 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
1186 BRD-K71035033 PC3 10 uM 24 h -0.3 -1.23 0.64 0.0 0.0 0.0
1261 BRD-K71035033 A549 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1376 BRD-K71035033 U2OS 10 uM 48 h -0.25 -1.06 0.25 0.0 0.0 0.0
35610 BRD-K71035033 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36333 BRD-K71035033 PHH 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
36630 BRD-K71035033 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36860 BRD-K71035033 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87304 BRD-K71035033 BJAB 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87355 BRD-K71035033 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87405 BRD-K71035033 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87453 BRD-K71035033 KMS34 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
87522 BRD-K71035033 MINO 10 uM 6 h 0.27 1.12 0.27 0.0 0.0 0.0
87557 BRD-K71035033 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87607 BRD-K71035033 OCILY10 2.5 uM 24 h -0.29 -1.21 0.6 -0.28 -0.93 0.35
87658 BRD-K71035033 OCILY19 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
87709 BRD-K71035033 OCILY3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87756 BRD-K71035033 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
87787 BRD-K71035033 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87847 BRD-K71035033 TMD8 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
91826 BRD-K71035033 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91947 BRD-K71035033 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.65 0.01
92936 BRD-K71035033 ASC 10 uM 24 h 0.35 1.44 1.12 0.0 0.0 0.0
92999 BRD-K71035033 CD34 10 uM 24 h 0.23 0.98 0.08 0.0 0.0 0.0
93087 BRD-K71035033 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93129 BRD-K71035033 HELA 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
93225 BRD-K71035033 HUVEC 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
93279 BRD-K71035033 JURKAT 10 uM 24 h 0.3 1.25 0.56 0.0 0.0 0.0
93360 BRD-K71035033 MDAMB231 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93419 BRD-K71035033 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93488 BRD-K71035033 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97268 BRD-K71035033 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116761 BRD-K71035033 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116810 BRD-K71035033 HCC515 10 uM 24 h -0.24 -1.02 0.17 0.0 0.0 0.0
116853 BRD-K71035033 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126367 BRD-K71035033 A375 10 uM 24 h -0.18 -0.77 0.0 0.0 0.0 0.0
126500 BRD-K71035033 HT29 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
126615 BRD-K71035033 YAPC 10 uM 24 h -0.26 -1.09 0.31 0.0 0.0 0.0
134547 BRD-K71035033 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).