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CMap Candidate Details

Structure:
CMap ID: C03245
Pert ID: BRD-K77987382
Compound Name: mebendazole
Targets: TUBA1A|TUBB|TUBB4B
MoA: tubulin polymerization inhibitor
SMILES: COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3052 BRD-K77987382 HA1E 10 uM 6 h 0.18 0.73 0.0 0.26 0.94 0.28
3261 BRD-K77987382 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3861 BRD-K77987382 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45033 BRD-K77987382 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45322 BRD-K77987382 HEPG2 10 uM 6 h -0.2 -0.83 0.0 -0.42 -1.41 2.02
46145 BRD-K77987382 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
46462 BRD-K77987382 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46786 BRD-K77987382 SKB 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.36
50053 BRD-K77987382 A549 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
50952 BRD-K77987382 PC3 10 uM 6 h -0.3 -1.24 0.67 0.0 0.0 0.0
91212 BRD-K77987382 HUH7 12 uM 72 h 0.21 0.87 0.01 -0.26 -0.89 0.26
97490 BRD-K77987382 NKDBA 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97671 BRD-K77987382 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.03 0.62
99502 BRD-K77987382 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
123800 BRD-K77987382 A375 3.33 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
123905 BRD-K77987382 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123946 BRD-K77987382 HELA 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
124006 BRD-K77987382 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124059 BRD-K77987382 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
124127 BRD-K77987382 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.05
124188 BRD-K77987382 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124240 BRD-K77987382 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132230 BRD-K77987382 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).