CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03257
Pert ID:	BRD-K50398167
Compound Name:	meclofenamic-acid
Targets:	ALOX5\|CNR1\|KCNQ2\|KCNQ3\|PTGS1\|PTGS2
MoA:	cyclooxygenase inhibitor; prostanoid receptor antagonist
SMILES:	Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3375	BRD-K50398167	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
3821	BRD-K50398167	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44981	BRD-K50398167	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45277	BRD-K50398167	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.99	0.5
46097	BRD-K50398167	NPC	10 uM	24 h	-0.28	-1.16	0.45	-0.21	-0.72	0.04
46736	BRD-K50398167	SKB	10 uM	24 h	0.3	1.24	0.53	0.0	0.0	0.0
99616	BRD-K50398167	U2OS	10 uM	6 h	-0.3	-1.27	0.74	-0.24	-0.81	0.13
125250	BRD-K50398167	A375	0.125 uM	24 h	0.0	0.0	0.0	0.31	1.08	0.66
125339	BRD-K50398167	HEK293	0.125 uM	24 h	0.26	1.1	0.24	-0.24	-0.8	0.12
125409	BRD-K50398167	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125425	BRD-K50398167	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.25
125465	BRD-K50398167	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125506	BRD-K50398167	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.35	1.24	1.25
133375	BRD-K50398167	A549	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133404	BRD-K50398167	HA1E	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133440	BRD-K50398167	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.3	1.04	0.56
133468	BRD-K50398167	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.76
133573	BRD-K50398167	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.25	0.88	0.18
133616	BRD-K50398167	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133650	BRD-K50398167	YAPC	0.08 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.51

Summary