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CMap Candidate Details

Structure:
CMap ID: C03269
Pert ID: BRD-A89585551
Compound Name: mefloquine
Targets: ADORA2A|HBA1
MoA: adenosine receptor antagonist; hemoglobin antagonist
SMILES: OC(C1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
100381 BRD-A89585551 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121729 BRD-A89585551 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121752 BRD-A89585551 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
121814 BRD-A89585551 HT29 10 uM 24 h 0.22 0.94 0.05 0.0 0.0 0.0
121859 BRD-A89585551 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129860 BRD-A89585551 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129887 BRD-A89585551 HELA 2.22 uM 24 h 0.31 1.3 0.69 0.0 0.0 0.0
129984 BRD-A89585551 MCF10A 0.01 uM 24 h -0.31 -1.28 0.74 0.33 1.15 0.9
130016 BRD-A89585551 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130071 BRD-A89585551 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130142 BRD-A89585551 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130177 BRD-A89585551 YAPC 2.22 uM 24 h -0.28 -1.17 0.48 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).