CMap Candidate Details
Structure:
| CMap ID: | C03275 |
| Pert ID: | BRD-K12244279 |
| Compound Name: | MEK1-2-inhibitor |
| Targets: | MAP2K2 |
| MoA: | MEK inhibitor |
| SMILES: | N\C(Sc1ccc(N)cc1)=C(\C#N)c1ccccc1C(F)(F)F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1741 | BRD-K12244279 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2084 | BRD-K12244279 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2541 | BRD-K12244279 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 44857 | BRD-K12244279 | ASC | 10 uM | 24 h | 0.23 | 0.95 | 0.06 | 0.0 | 0.0 | 0.0 |
| 45430 | BRD-K12244279 | HT29 | 10 uM | 6 h | 0.22 | 0.93 | 0.04 | 0.41 | 1.47 | 2.24 |
| 45652 | BRD-K12244279 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 45972 | BRD-K12244279 | NPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 46292 | BRD-K12244279 | PHH | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 46607 | BRD-K12244279 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97324 | BRD-K12244279 | HAP1 | 0.66 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97360 | BRD-K12244279 | A375 | 3.33 uM | 24 h | 0.2 | 0.81 | 0.0 | 0.0 | 0.0 | 0.0 |
| 100092 | BRD-K12244279 | U2OS | 10 uM | 6 h | -0.19 | -0.81 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116010 | BRD-K12244279 | A549 | 10 uM | 24 h | -0.31 | -1.28 | 0.77 | 0.26 | 0.92 | 0.25 |
| 116136 | BRD-K12244279 | HEPG2 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116260 | BRD-K12244279 | PC3 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.26 | 0.91 | 0.24 |