CMap Candidate Details
Structure:
| CMap ID: | C03291 |
| Pert ID: | BRD-A45889380 |
| Compound Name: | mepacrine |
| Targets: | PLA2G1B|PLA2G4A|PLA2G6|PLCL1 |
| MoA: | cytokine production inhibitor; NFkB pathway inhibitor; TP53 activator |
| SMILES: | CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 9036 | BRD-A45889380 | A375 | 10 uM | 6 h | -0.29 | -1.21 | 0.57 | 0.0 | 0.0 | 0.0 |
| 9292 | BRD-A45889380 | AGS | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 9594 | BRD-A45889380 | H1299 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |
| 10164 | BRD-A45889380 | HCC515 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 10402 | BRD-A45889380 | HCT116 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.5 |
| 10669 | BRD-A45889380 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 11076 | BRD-A45889380 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 11343 | BRD-A45889380 | NCIH2073 | 10 uM | 6 h | 0.22 | 0.93 | 0.05 | 0.0 | 0.0 | 0.0 |
| 11656 | BRD-A45889380 | NCIH508 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.26 | 1.38 |
| 11915 | BRD-A45889380 | NCIH596 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.38 | 2.02 |
| 12667 | BRD-A45889380 | SW480 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 13007 | BRD-A45889380 | THP1 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.24 | 1.34 |
| 13149 | BRD-A45889380 | U937 | 10 uM | 6 h | -0.25 | -1.03 | 0.19 | 0.0 | 0.0 | 0.0 |
| 13423 | BRD-A45889380 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 51378 | BRD-A45889380 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97270 | BRD-A45889380 | HAP1 | 3.33 uM | 24 h | -0.22 | -0.9 | 0.04 | 0.24 | 0.86 | 0.16 |
| 125618 | BRD-A45889380 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125632 | BRD-A45889380 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.23 | 1.25 |
| 125675 | BRD-A45889380 | HELA | 10 uM | 24 h | 0.22 | 0.93 | 0.05 | 0.0 | 0.0 | 0.0 |
| 125741 | BRD-A45889380 | HUVEC | 10 uM | 24 h | -0.23 | -0.95 | 0.09 | 0.0 | 0.0 | 0.0 |
| 125781 | BRD-A45889380 | JURKAT | 10 uM | 24 h | -0.24 | -1.0 | 0.15 | 0.0 | 0.0 | 0.0 |
| 125803 | BRD-A45889380 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.09 | 0.84 |
| 125854 | BRD-A45889380 | MDAMB231 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125939 | BRD-A45889380 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133735 | BRD-A45889380 | HEK293 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133947 | BRD-A45889380 | PC3 | 2.22 uM | 24 h | -0.2 | -0.85 | 0.01 | 0.23 | 0.81 | 0.09 |