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CMap Candidate Details

Structure:
CMap ID: C03306
Pert ID: BRD-K45152786
Compound Name: merbarone
Targets: TOP2A
MoA: topoisomerase inhibitor
SMILES: O=C(Nc1ccccc1)C1C(=O)NC(=S)NC1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125582 BRD-K45152786 A375 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
125631 BRD-K45152786 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
125653 BRD-K45152786 HEK293 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.95
125734 BRD-K45152786 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
125802 BRD-K45152786 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125850 BRD-K45152786 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125874 BRD-K45152786 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125893 BRD-K45152786 THP1 3.33 uM 24 h -0.29 -1.19 0.54 0.0 0.0 0.0
125932 BRD-K45152786 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133667 BRD-K45152786 A549 2.22 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
133766 BRD-K45152786 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133799 BRD-K45152786 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133825 BRD-K45152786 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133883 BRD-K45152786 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).