CMap Candidate Details
Structure:
| CMap ID: | C03327 |
| Pert ID: | BRD-K27182532 |
| Compound Name: | metatinib |
| Targets: | ABL1|BCR |
| MoA: | Bcr-Abl kinase inhibitor |
| SMILES: | Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95329 | BRD-K27182532 | A549 | 10 uM | 6 h | 0.18 | 0.73 | 0.0 | 0.34 | 1.21 | 1.15 |
| 95415 | BRD-K27182532 | U2OS | 10 uM | 48 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.89 | 0.26 |
| 120879 | BRD-K27182532 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.32 | 1.13 | 0.8 |
| 120924 | BRD-K27182532 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120980 | BRD-K27182532 | HEK293 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121007 | BRD-K27182532 | HELA | 10 uM | 3 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.91 | 0.31 |
| 121023 | BRD-K27182532 | HT29 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.4 | 1.43 | 2.2 |
| 121063 | BRD-K27182532 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.18 | 1.14 |
| 121137 | BRD-K27182532 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129237 | BRD-K27182532 | PC3 | 2.22 uM | 24 h | 0.22 | 0.91 | 0.03 | 0.0 | 0.0 | 0.0 |