CMap Candidate Details
Structure:
| CMap ID: | C03348 |
| Pert ID: | BRD-K59456551 |
| Compound Name: | methotrexate |
| Targets: | DHFR |
| MoA: | dihydrofolate reductase inhibitor |
| SMILES: | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 24460 | BRD-K59456551 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 24591 | BRD-K59456551 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.18 | 0.63 | 0.0 |
| 24795 | BRD-K59456551 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 24928 | BRD-K59456551 | HT29 | 10 uM | 6 h | -0.21 | -0.89 | 0.03 | 0.32 | 1.15 | 0.88 |
| 25397 | BRD-K59456551 | VCAP | 10 uM | 24 h | -0.22 | -0.92 | 0.06 | -0.28 | -0.93 | 0.35 |
| 51231 | BRD-K59456551 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.96 | 0.44 |
| 51492 | BRD-K59456551 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.4 | -1.35 | 2.02 |
| 52925 | BRD-K59456551 | HEPG2 | 20 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 53321 | BRD-K59456551 | MCF10A | 12 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |