CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03420
Pert ID:	BRD-K02867583
Compound Name:	minaprine
Targets:	ACHE\|CHRM1\|DRD1\|DRD2\|HTR2A\|HTR2B\|HTR2C\|MAOA\|SLC6A4
MoA:	serotonin reuptake inhibitor
SMILES:	Cc1cc(nnc1NCCN1CCOCC1)-c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6717	BRD-K02867583	A375	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.13
8641	BRD-K02867583	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122905	BRD-K02867583	HEK293	0.125 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
122981	BRD-K02867583	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123030	BRD-K02867583	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123077	BRD-K02867583	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	-0.22	-0.74	0.05
123120	BRD-K02867583	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123150	BRD-K02867583	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123192	BRD-K02867583	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131252	BRD-K02867583	A549	0.25 uM	24 h	0.22	0.91	0.03	0.0	0.0	0.0
131285	BRD-K02867583	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131311	BRD-K02867583	HELA	0.03 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7
131368	BRD-K02867583	HUVEC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131406	BRD-K02867583	MCF10A	0.08 uM	24 h	-0.22	-0.91	0.06	0.21	0.74	0.04
131505	BRD-K02867583	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary