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CMap Candidate Details

Structure:
CMap ID: C03430
Pert ID: BRD-K82967685
Compound Name: mirodenafil
Targets: PDE5A
MoA: phosphodiesterase inhibitor
SMILES: CCCOc1ccc(cc1-c1nc2c(CCC)cn(CC)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCO)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126031 BRD-K82967685 HELA 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
126053 BRD-K82967685 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
126082 BRD-K82967685 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126128 BRD-K82967685 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126181 BRD-K82967685 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.52
126220 BRD-K82967685 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126238 BRD-K82967685 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
126264 BRD-K82967685 PC3 0.125 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
126300 BRD-K82967685 THP1 3.33 uM 24 h -0.26 -1.1 0.34 -0.35 -1.16 1.11
126340 BRD-K82967685 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
134007 BRD-K82967685 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134038 BRD-K82967685 A549 0.03 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
134066 BRD-K82967685 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134102 BRD-K82967685 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).