CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03436
Pert ID:	BRD-A48237631
Compound Name:	mitomycin-c
Targets:
MoA:	DNA alkylating agent; DNA synthesis inhibitor
SMILES:	CO[C@@]12[C@@H]3NC3CN1C1=C([C@@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1168	BRD-A48237631	MCF??7.00	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
1368	BRD-A48237631	U2OS	1.11 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
5158	BRD-A48237631	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5403	BRD-A48237631	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5729	BRD-A48237631	HCC515	10 uM	6 h	0.22	0.92	0.04	0.0	0.0	0.0
6245	BRD-A48237631	PC3	10 uM	6 h	-0.16	-0.68	0.0	0.0	0.0	0.0
6332	BRD-A48237631	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.36
37506	BRD-A48237631	ASC	10 uM	24 h	0.22	0.93	0.05	-0.31	-1.05	0.7
37826	BRD-A48237631	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38019	BRD-A48237631	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38357	BRD-A48237631	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96013	BRD-A48237631	PHH	3.33 uM	24 h	0.27	1.12	0.27	0.0	0.0	0.0
125316	BRD-A48237631	HEK293	3.33 uM	24 h	0.21	0.86	0.01	0.0	0.0	0.0
125353	BRD-A48237631	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.12
125399	BRD-A48237631	JURKAT	10 uM	24 h	0.24	0.99	0.1	0.0	0.0	0.0
125416	BRD-A48237631	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125474	BRD-A48237631	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125520	BRD-A48237631	THP1	3.33 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
125548	BRD-A48237631	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.3	1.07	0.63
133366	BRD-A48237631	A549	0.74 uM	24 h	0.24	1.0	0.11	0.0	0.0	0.0

Summary