CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03455
Pert ID:	BRD-K66911501
Compound Name:	MK-3207
Targets:	CALCA
MoA:	calcitonin antagonist
SMILES:	Fc1cc(F)cc(c1)[C@@H]1CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
124948	BRD-K66911501	A375	0.37 uM	24 h	0.21	0.86	0.01	-0.34	-1.16	1.11
124983	BRD-K66911501	A549	0.125 uM	24 h	0.24	0.99	0.09	0.0	0.0	0.0
125010	BRD-K66911501	HA1E	0.125 uM	24 h	0.31	1.29	0.67	0.0	0.0	0.0
125124	BRD-K66911501	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125140	BRD-K66911501	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125185	BRD-K66911501	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.73
133075	BRD-K66911501	HEK293	0.25 uM	24 h	-0.21	-0.86	0.02	-0.38	-1.27	1.43
133102	BRD-K66911501	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.3	1.07	0.63
133131	BRD-K66911501	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.22	0.79	0.07
133181	BRD-K66911501	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
133210	BRD-K66911501	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133243	BRD-K66911501	MCF??7.00	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133326	BRD-K66911501	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary