CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03472
Pert ID:	BRD-K44432556
Compound Name:	ML-228
Targets:	HIF1A
MoA:	hypoxia inducible factor activator
SMILES:	C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
17346	BRD-K44432556	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
18288	BRD-K44432556	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
18592	BRD-K44432556	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
26365	BRD-K44432556	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
27941	BRD-K44432556	NEU	10 uM	24 h	-0.18	-0.76	0.0	-0.37	-1.25	1.35
28253	BRD-K44432556	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
28887	BRD-K44432556	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
29217	BRD-K44432556	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118384	BRD-K44432556	A375	1.11 uM	24 h	-0.25	-1.03	0.2	-0.36	-1.21	1.24
118422	BRD-K44432556	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118455	BRD-K44432556	HA1E	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118496	BRD-K44432556	HCC515	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118582	BRD-K44432556	HT29	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118619	BRD-K44432556	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary