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CMap Candidate Details

Structure:
CMap ID: C03483
Pert ID: BRD-K83963101
Compound Name: MLN-8054
Targets: AURKA
MoA: Aurora kinase inhibitor
SMILES: OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33575 BRD-K83963101 A375 10 uM 6 h -0.19 -0.79 0.0 0.0 0.0 0.0
34975 BRD-K83963101 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36365 BRD-K83963101 PHH 10 uM 24 h -0.21 -0.9 0.04 -0.23 -0.78 0.09
36663 BRD-K83963101 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37011 BRD-K83963101 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91525 BRD-K83963101 BT20 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91586 BRD-K83963101 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91751 BRD-K83963101 SKBR3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94473 BRD-K83963101 ASC 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
94536 BRD-K83963101 CD34 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94589 BRD-K83963101 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94730 BRD-K83963101 HME1 0.37 uM 24 h 0.24 1.0 0.11 0.24 0.84 0.13
94876 BRD-K83963101 JURKAT 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
95003 BRD-K83963101 NEU 0.37 uM 24 h -0.26 -1.1 0.35 -0.37 -1.24 1.34
95088 BRD-K83963101 NPC 10 uM 24 h 0.33 1.37 0.97 -0.28 -0.94 0.36
95110 BRD-K83963101 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
95149 BRD-K83963101 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95199 BRD-K83963101 SKL 0.04 uM 24 h -0.24 -0.99 0.13 -0.2 -0.66 0.01
95262 BRD-K83963101 THP1 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
126008 BRD-K83963101 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126057 BRD-K83963101 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
126087 BRD-K83963101 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
126187 BRD-K83963101 MCF10A 10 uM 24 h 0.29 1.22 0.48 0.21 0.76 0.05
126223 BRD-K83963101 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
126343 BRD-K83963101 YAPC 3.33 uM 24 h -0.26 -1.09 0.33 -0.33 -1.1 0.85
134042 BRD-K83963101 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134109 BRD-K83963101 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
134154 BRD-K83963101 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
134262 BRD-K83963101 MDAMB231 2.22 uM 24 h 0.31 1.3 0.72 -0.29 -0.98 0.49
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).