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CMap Candidate Details

Structure:
CMap ID: C03531
Pert ID: BRD-K99616396
Compound Name: motesanib
Targets: FLT1|FLT4|KDR|KIT
MoA: KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES: CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
31570 BRD-K99616396 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31952 BRD-K99616396 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33193 BRD-K99616396 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34728 BRD-K99616396 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36397 BRD-K99616396 PHH 10 uM 24 h -0.19 -0.81 0.0 0.28 0.99 0.39
36907 BRD-K99616396 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.47
91528 BRD-K99616396 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91615 BRD-K99616396 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91704 BRD-K99616396 MDAMB231 0.37 uM 24 h -0.2 -0.83 0.0 -0.28 -0.93 0.35
91739 BRD-K99616396 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
92877 BRD-K99616396 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92904 BRD-K99616396 A549 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
92944 BRD-K99616396 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93013 BRD-K99616396 CD34 10 uM 24 h 0.24 0.98 0.09 -0.26 -0.86 0.22
93052 BRD-K99616396 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
93100 BRD-K99616396 HEK293 1.11 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
93141 BRD-K99616396 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93183 BRD-K99616396 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
93239 BRD-K99616396 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93291 BRD-K99616396 JURKAT 10 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
93327 BRD-K99616396 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
93428 BRD-K99616396 NPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93458 BRD-K99616396 PC3 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.19
93517 BRD-K99616396 SKL 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
93555 BRD-K99616396 THP1 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
93596 BRD-K99616396 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).