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CMap Candidate Details

Structure:
CMap ID: C03535
Pert ID: BRD-K61988078
Compound Name: moxidectin
Targets:
MoA: chloride channel antagonist
SMILES: CO\N=C1\C[C@]2(C[C@@H]3C[C@@H](C\C=C(C)\C[C@@H](C)\C=C\C=C4/CO[C@@H]5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)C(\C)=C\C(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124586 BRD-K61988078 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124627 BRD-K61988078 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
124672 BRD-K61988078 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124769 BRD-K61988078 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124812 BRD-K61988078 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124855 BRD-K61988078 PC3 10 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.04
124921 BRD-K61988078 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132703 BRD-K61988078 A549 2.22 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
132769 BRD-K61988078 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132816 BRD-K61988078 HT29 2.22 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
132845 BRD-K61988078 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132884 BRD-K61988078 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
132935 BRD-K61988078 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).