CMap Candidate Details
Structure:
| CMap ID: | C03597 |
| Pert ID: | BRD-K06674495 |
| Compound Name: | nafamostat |
| Targets: | ASIC1|ASIC2|ASIC3|C1R|PRSS1|TPSAB1|TRPM7 |
| MoA: | serine protease inhibitor |
| SMILES: | NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122545 | BRD-K06674495 | A375 | 10 uM | 24 h | 0.26 | 1.1 | 0.24 | 0.0 | 0.0 | 0.0 |
| 122576 | BRD-K06674495 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.32 | 1.13 | 0.83 |
| 122718 | BRD-K06674495 | MCF10A | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122752 | BRD-K06674495 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.2 | 1.22 |
| 122814 | BRD-K06674495 | YAPC | 1.11 uM | 24 h | -0.25 | -1.06 | 0.26 | -0.27 | -0.91 | 0.31 |
| 130913 | BRD-K06674495 | HA1E | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130934 | BRD-K06674495 | HEK293 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130964 | BRD-K06674495 | HELA | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130997 | BRD-K06674495 | HT29 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131040 | BRD-K06674495 | HUVEC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131117 | BRD-K06674495 | MDAMB231 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 131150 | BRD-K06674495 | PC3 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.83 | 0.12 |