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CMap Candidate Details

Structure:
CMap ID: C03648
Pert ID: BRD-K90789829
Compound Name: nefazodone
Targets: ADRA1A|ADRA1B|ADRA2A|CYP3A4|HTR1A|HTR2A|HTR2C|SLC6A2|SLC6A3|SLC6A4
MoA: adrenergic inhibitor; norepinephrine reuptake inhibitor; serotonin receptor antagonist; serotonin reuptake inhibitor
SMILES: CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CCOc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3403 BRD-K90789829 HCC515 10 uM 6 h -0.23 -0.97 0.11 0.3 1.06 0.6
3990 BRD-K90789829 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39365 BRD-K90789829 A549 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.72
39821 BRD-K90789829 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
40111 BRD-K90789829 HEPG2 10 uM 6 h -0.19 -0.81 0.0 0.0 0.0 0.0
41244 BRD-K90789829 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
41584 BRD-K90789829 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91260 BRD-K90789829 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121730 BRD-K90789829 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
121815 BRD-K90789829 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
121860 BRD-K90789829 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121882 BRD-K90789829 YAPC 0.04 uM 24 h 0.21 0.88 0.01 0.32 1.13 0.85
129806 BRD-K90789829 HA1E 0.01 uM 24 h 0.18 0.76 0.0 -0.33 -1.12 0.93
129861 BRD-K90789829 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
129888 BRD-K90789829 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129985 BRD-K90789829 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130017 BRD-K90789829 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130072 BRD-K90789829 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130143 BRD-K90789829 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).