CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03653
Pert ID:	BRD-M80207679
Compound Name:	nemonapride
Targets:	DRD2\|DRD3\|DRD4
MoA:	dopamine receptor antagonist
SMILES:	CNc1cc(OC)c(cc1Cl)C(=O)N[C@@H]1CCN(Cc2ccccc2)[C@@H]1C.CNc1cc(OC)c(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccccc2)[C@H]1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125958	BRD-M80207679	A375	1.11 uM	24 h	0.26	1.09	0.23	0.31	1.1	0.71
125975	BRD-M80207679	A549	3.33 uM	24 h	-0.24	-1.0	0.15	0.0	0.0	0.0
126066	BRD-M80207679	HUVEC	3.33 uM	24 h	-0.24	-1.01	0.16	-0.22	-0.73	0.05
126106	BRD-M80207679	JURKAT	1.11 uM	24 h	-0.35	-1.46	1.43	0.0	0.0	0.0
126161	BRD-M80207679	MCF10A	1.11 uM	24 h	0.31	1.27	0.58	0.0	0.0	0.0
126212	BRD-M80207679	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126228	BRD-M80207679	MDAMB231	10 uM	24 h	-0.15	-0.64	0.0	0.23	0.83	0.11
126279	BRD-M80207679	THP1	1.11 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25
134058	BRD-M80207679	HA1E	0.08 uM	24 h	0.29	1.2	0.43	0.0	0.0	0.0
134080	BRD-M80207679	HEK293	0.25 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
134135	BRD-M80207679	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134171	BRD-M80207679	HT29	2.22 uM	24 h	0.2	0.82	0.0	0.0	0.0	0.0
134280	BRD-M80207679	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.85
134301	BRD-M80207679	YAPC	0.01 uM	24 h	-0.24	-0.99	0.13	-0.37	-1.25	1.35

Summary