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CMap Candidate Details

Structure:
CMap ID: C03685
Pert ID: BRD-A26711594
Compound Name: nicardipine
Targets: ADORA3|ADRA1A|ADRA1B|ADRA1D|CACNA1C|CACNA1D|CACNA2D1|CACNB2|CALM1|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|PDE1A|PDE1B
MoA: calcium channel blocker
SMILES: COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7517 BRD-A26711594 HCC515 10 uM 6 h 0.26 1.07 0.19 0.0 0.0 0.0
9280 BRD-A26711594 AGS 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
10392 BRD-A26711594 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10661 BRD-A26711594 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.77 0.08
11103 BRD-A26711594 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11214 BRD-A26711594 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11333 BRD-A26711594 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11648 BRD-A26711594 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.16 1.11
12198 BRD-A26711594 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12658 BRD-A26711594 SW480 10 uM 6 h 0.22 0.9 0.02 -0.18 -0.62 0.0
13068 BRD-A26711594 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13138 BRD-A26711594 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13530 BRD-A26711594 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90943 BRD-A26711594 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
119937 BRD-A26711594 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119976 BRD-A26711594 A549 0.37 uM 24 h -0.3 -1.23 0.64 0.0 0.0 0.0
120046 BRD-A26711594 HELA 10 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
120177 BRD-A26711594 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128806 BRD-A26711594 HA1E 0.08 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
128863 BRD-A26711594 YAPC 0.01 uM 24 h -0.26 -1.07 0.28 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).