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CMap Candidate Details

Structure:
CMap ID: C03716
Pert ID: BRD-A95696066
Compound Name: nisoxetine
Targets: SLC6A2|SLC6A3|SLC6A4
MoA: norepinephrine reuptake inhibitor
SMILES: CNCCC(Oc1ccccc1OC)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2062 BRD-A95696066 HCC515 10 uM 6 h -0.28 -1.15 0.44 0.33 1.17 0.93
2530 BRD-A95696066 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42247 BRD-A95696066 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43138 BRD-A95696066 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91093 BRD-A95696066 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98123 BRD-A95696066 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98520 BRD-A95696066 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
100415 BRD-A95696066 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
128387 BRD-A95696066 A549 0.37 uM 24 h 0.23 0.94 0.06 0.29 1.01 0.46
128442 BRD-A95696066 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128552 BRD-A95696066 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
128596 BRD-A95696066 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128644 BRD-A95696066 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
128683 BRD-A95696066 PC3 0.125 uM 24 h 0.23 0.95 0.07 0.0 0.0 0.0
128724 BRD-A95696066 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
128770 BRD-A95696066 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
136184 BRD-A95696066 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136228 BRD-A95696066 HA1E 0.03 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
136264 BRD-A95696066 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136293 BRD-A95696066 HT29 0.03 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).