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CMap Candidate Details

Structure:
CMap ID: C00372
Pert ID: BRD-K91308639
Compound Name: apalutamide
Targets:
MoA: androgen receptor antagonist
SMILES: CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127742 BRD-K91308639 A375 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.54 15.35
127786 BRD-K91308639 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
127822 BRD-K91308639 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.02
127866 BRD-K91308639 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127900 BRD-K91308639 HT29 10 uM 24 h -0.31 -1.31 0.82 -0.42 -1.4 2.02
127940 BRD-K91308639 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127993 BRD-K91308639 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128028 BRD-K91308639 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128051 BRD-K91308639 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135567 BRD-K91308639 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
135658 BRD-K91308639 JURKAT 0.25 uM 24 h 0.21 0.89 0.02 -0.31 -1.03 0.63
135744 BRD-K91308639 YAPC 2.22 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).