CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03824
Pert ID:	BRD-K21025364
Compound Name:	NVP-TAE226
Targets:	PTK2
MoA:	protein tyrosine kinase inhibitor
SMILES:	CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
92878	BRD-K21025364	A375	0.12 uM	24 h	-0.22	-0.93	0.07	-0.38	-1.28	1.45
92905	BRD-K21025364	A549	10 uM	24 h	-0.27	-1.12	0.39	0.0	0.0	0.0
92945	BRD-K21025364	ASC	3.33 uM	24 h	0.0	0.0	0.0	-0.37	-1.26	1.35
93014	BRD-K21025364	CD34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93053	BRD-K21025364	HA1E	1.11 uM	24 h	0.28	1.19	0.41	0.0	0.0	0.0
93101	BRD-K21025364	HEK293	3.33 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.08
93142	BRD-K21025364	HELA	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
93184	BRD-K21025364	HEPG2	10 uM	24 h	0.17	0.72	0.0	-0.28	-0.95	0.39
93240	BRD-K21025364	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93292	BRD-K21025364	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93328	BRD-K21025364	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93370	BRD-K21025364	MDAMB231	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.35
93429	BRD-K21025364	NPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93459	BRD-K21025364	PC3	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93518	BRD-K21025364	SKL	1.11 uM	24 h	0.0	0.0	0.0	0.19	0.66	0.01
93556	BRD-K21025364	THP1	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
93597	BRD-K21025364	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.1

Summary