CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03865
Pert ID:	BRD-K18895904
Compound Name:	olanzapine
Targets:	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|ADRB3\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR1F\|HTR2A\|HTR2B\|HTR2C\|HTR3A\|HTR5A\|HTR6\|HTR7
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1437	BRD-K18895904	NPC	12.5 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
24560	BRD-K18895904	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
25335	BRD-K18895904	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91121	BRD-K18895904	HUH7	10 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
121379	BRD-K18895904	HA1E	10 uM	24 h	-0.22	-0.92	0.06	-0.25	-0.86	0.21
121472	BRD-K18895904	PC3	0.04 uM	24 h	-0.28	-1.15	0.44	0.0	0.0	0.0
121492	BRD-K18895904	YAPC	0.125 uM	24 h	0.31	1.29	0.67	-0.31	-1.03	0.62
129394	BRD-K18895904	A375	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129457	BRD-K18895904	HELA	0.03 uM	24 h	0.27	1.14	0.31	0.35	1.24	1.25
129479	BRD-K18895904	HT29	0.74 uM	24 h	0.36	1.49	1.16	0.21	0.76	0.05
129506	BRD-K18895904	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	0.34	1.22	1.15

Summary