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CMap Candidate Details

Structure:
CMap ID: C03874
Pert ID: BRD-A81541225
Compound Name: oligomycin-a
Targets: ATP5A1
MoA: ATP synthase inhibitor; ATPase inhibitor
SMILES: CCC1CCC2OC3(CC[C@@H](C)C(C[C@H](C)O)O3)[C@H](C)C(OC(=O)\C=C\[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)C\C=C\C=C\1)[C@H]2C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9031 BRD-A81541225 A375 10 uM 6 h -0.23 -0.96 0.1 0.25 0.88 0.19
9154 BRD-A81541225 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9314 BRD-A81541225 AGS 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.7
9617 BRD-A81541225 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10016 BRD-A81541225 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10292 BRD-A81541225 HCC515 10 uM 6 h -0.21 -0.89 0.04 0.0 0.0 0.0
10421 BRD-A81541225 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11370 BRD-A81541225 NCIH2073 10 uM 6 h 0.17 0.71 0.0 -0.21 -0.71 0.03
11676 BRD-A81541225 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.35
11939 BRD-A81541225 NCIH596 10 uM 6 h 0.21 0.88 0.01 0.0 0.0 0.0
13168 BRD-A81541225 U937 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
13553 BRD-A81541225 VCAP 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.85
95983 BRD-A81541225 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119673 BRD-A81541225 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119710 BRD-A81541225 HT29 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
119759 BRD-A81541225 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119798 BRD-A81541225 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.64
119831 BRD-A81541225 PC3 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).