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CMap Candidate Details

Structure:
CMap ID: C03899
Pert ID: BRD-A13689093
Compound Name: ONO-4059
Targets: BTK
MoA: Bruton's tyrosine kinase (BTK) inhibitor
SMILES: Nc1ncnc2n(C3CCCN(C3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87294 BRD-A13689093 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87379 BRD-A13689093 HBL1 0.125 uM 24 h -0.3 -1.24 0.64 -0.32 -1.08 0.8
87428 BRD-A13689093 K562 2.5 uM 24 h 0.23 0.97 0.08 -0.36 -1.21 1.24
87477 BRD-A13689093 KMS34 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87492 BRD-A13689093 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87580 BRD-A13689093 NALM6 2.5 uM 24 h -0.27 -1.12 0.38 0.33 1.18 0.99
87632 BRD-A13689093 OCILY10 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
87681 BRD-A13689093 OCILY19 10 uM 24 h -0.24 -1.02 0.17 0.0 0.0 0.0
87732 BRD-A13689093 OCILY3 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87780 BRD-A13689093 SKMEL5 10 uM 24 h -0.18 -0.75 0.0 0.25 0.89 0.2
87824 BRD-A13689093 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87874 BRD-A13689093 TMD8 10 uM 6 h 0.0 0.0 0.0 0.33 1.16 0.9
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).