CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04014
Pert ID:	BRD-K83794243
Compound Name:	palovarotene
Targets:	RARG
MoA:	retinoid receptor agonist
SMILES:	CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)c(Cn3cccn3)cc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126056	BRD-K83794243	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126086	BRD-K83794243	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.97
126134	BRD-K83794243	JURKAT	10 uM	24 h	-0.28	-1.18	0.5	-0.26	-0.86	0.21
126186	BRD-K83794243	MCF10A	10 uM	24 h	-0.25	-1.04	0.21	0.23	0.8	0.08
126241	BRD-K83794243	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126267	BRD-K83794243	PC3	10 uM	24 h	0.25	1.04	0.15	0.0	0.0	0.0
126305	BRD-K83794243	THP1	10 uM	24 h	-0.27	-1.13	0.41	0.0	0.0	0.0
134011	BRD-K83794243	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134041	BRD-K83794243	A549	0.25 uM	24 h	-0.29	-1.22	0.61	0.0	0.0	0.0
134069	BRD-K83794243	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.53	-1.77	15.65
134108	BRD-K83794243	HEK293	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134153	BRD-K83794243	HELA	2.22 uM	24 h	-0.21	-0.86	0.02	-0.36	-1.22	1.24
134231	BRD-K83794243	MCF??7.00	0.08 uM	24 h	0.31	1.29	0.64	-0.31	-1.03	0.64
134317	BRD-K83794243	YAPC	0.08 uM	24 h	-0.22	-0.9	0.04	0.0	0.0	0.0

Summary