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CMap Candidate Details

Structure:
CMap ID: C04041
Pert ID: BRD-K28120222
Compound Name: parthenolide-(alternate-stereo)
Targets: IKBKB|RELA
MoA: NFkB pathway inhibitor
SMILES: C\C1=C/CC[C@@]2(C)O[C@@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29818 BRD-K28120222 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30184 BRD-K28120222 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30406 BRD-K28120222 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30718 BRD-K28120222 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31006 BRD-K28120222 HCC515 10 uM 6 h -0.21 -0.86 0.02 0.21 0.76 0.05
31311 BRD-K28120222 HEPG2 10 uM 6 h 0.19 0.8 0.0 -0.28 -0.96 0.43
31599 BRD-K28120222 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32012 BRD-K28120222 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32159 BRD-K28120222 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32392 BRD-K28120222 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32757 BRD-K28120222 PC3 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.12
32990 BRD-K28120222 SKB 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
33268 BRD-K28120222 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).