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CMap Candidate Details

Structure:
CMap ID: C04044
Pert ID: BRD-K74514084
Compound Name: pazopanib
Targets: CSF1R|FGF1|FGFR1|FGFR3|FLT1|FLT4|ITK|KDR|KIT|PDGFRA|PDGFRB|SH2B3
MoA: KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES: CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
12 BRD-K74514084 NCIH2073 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
20 BRD-K74514084 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29 BRD-K74514084 NCIH596 10 uM 3 h 0.0 0.0 0.0 -0.5 -1.68 15.65
35 BRD-K74514084 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
68 BRD-K74514084 BJAB 2.5 uM 4 h 0.0 0.0 0.0 -0.27 -0.9 0.29
101 BRD-K74514084 HBL1 2.5 uM 24 h -0.26 -1.07 0.27 0.15 0.53 0.0
134 BRD-K74514084 K562 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
192 BRD-K74514084 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
231 BRD-K74514084 NALM6 0.66 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
271 BRD-K74514084 OCILY10 10 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
295 BRD-K74514084 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.01
345 BRD-K74514084 OCILY3 10 uM 24 h -0.29 -1.21 0.58 -0.33 -1.11 0.91
389 BRD-K74514084 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
449 BRD-K74514084 TMD8 10 uM 24 h -0.28 -1.19 0.51 0.0 0.0 0.0
33540 BRD-K74514084 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34676 BRD-K74514084 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.46 -1.53 15.35
34950 BRD-K74514084 HEPG2 10 uM 6 h -0.24 -0.98 0.12 -0.42 -1.43 15.35
35341 BRD-K74514084 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36341 BRD-K74514084 PHH 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
36637 BRD-K74514084 SKB 10 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
37000 BRD-K74514084 VCAP 10 uM 6 h -0.29 -1.23 0.62 0.31 1.09 0.67
82800 BRD-K74514084 A549 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
90606 BRD-K74514084 HCT116 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
91285 BRD-K74514084 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
91831 BRD-K74514084 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91918 BRD-K74514084 MDAMB231 0.08 uM 6 h 0.0 0.0 0.0 -0.34 -1.13 0.98
92935 BRD-K74514084 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92998 BRD-K74514084 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93086 BRD-K74514084 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93224 BRD-K74514084 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
93397 BRD-K74514084 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93511 BRD-K74514084 SKL 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95699 BRD-K74514084 U2OS 10 uM 6 h -0.23 -0.94 0.08 0.0 0.0 0.0
116881 BRD-K74514084 HT29 10 uM 24 h -0.28 -1.15 0.43 0.0 0.0 0.0
116969 BRD-K74514084 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127430 BRD-K74514084 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127468 BRD-K74514084 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127521 BRD-K74514084 JURKAT 10 uM 24 h -0.24 -1.0 0.14 0.33 1.16 0.9
127558 BRD-K74514084 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.01
127649 BRD-K74514084 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
127691 BRD-K74514084 YAPC 10 uM 24 h 0.0 0.0 0.0 0.22 0.8 0.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).