CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04046
Pert ID:	BRD-A29289453
Compound Name:	PCA-4248
Targets:	PTAFR
MoA:	platelet activating factor receptor antagonist
SMILES:	COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSc1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3095	BRD-A29289453	HCC515	10 uM	24 h	-0.26	-1.07	0.28	0.0	0.0	0.0
3433	BRD-A29289453	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3922	BRD-A29289453	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44757	BRD-A29289453	ASC	10 uM	24 h	-0.23	-0.97	0.11	0.0	0.0	0.0
45078	BRD-A29289453	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45877	BRD-A29289453	NPC	10 uM	24 h	0.2	0.84	0.0	0.28	0.99	0.42
46190	BRD-A29289453	PHH	10 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.84
46507	BRD-A29289453	SKB	10 uM	24 h	-0.32	-1.32	0.82	0.0	0.0	0.0
119950	BRD-A29289453	A375	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119992	BRD-A29289453	A549	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120028	BRD-A29289453	HA1E	10 uM	24 h	0.29	1.22	0.48	-0.35	-1.18	1.14
120055	BRD-A29289453	HELA	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.29	1.53
120109	BRD-A29289453	HT29	1.11 uM	24 h	0.0	0.0	0.0	-0.25	-0.84	0.18
120151	BRD-A29289453	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128874	BRD-A29289453	YAPC	0.03 uM	24 h	0.28	1.16	0.35	-0.28	-0.93	0.35

Summary