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CMap Candidate Details

Structure:
CMap ID: C04048
Pert ID: BRD-K71223042
Compound Name: PCI-29732
Targets: BTK
MoA: Bruton's tyrosine kinase (BTK) inhibitor
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87303 BRD-K71223042 BJAB 10 uM 3 h 0.0 0.0 0.0 -0.26 -0.89 0.26
87354 BRD-K71223042 HBL1 10 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
87404 BRD-K71223042 K562 2.5 uM 24 h 0.19 0.8 0.0 0.35 1.25 1.28
87451 BRD-K71223042 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87521 BRD-K71223042 MINO 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.97
87555 BRD-K71223042 NALM6 0.66 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
87606 BRD-K71223042 OCILY10 2.5 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
87656 BRD-K71223042 OCILY19 10 uM 24 h -0.2 -0.82 0.0 -0.36 -1.22 1.25
87708 BRD-K71223042 OCILY3 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87755 BRD-K71223042 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87803 BRD-K71223042 THP1 10 uM 3 h -0.36 -1.48 1.43 -0.43 -1.46 15.35
87833 BRD-K71223042 TMD8 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).