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CMap Candidate Details

Structure:
CMap ID: C04051
Pert ID: BRD-K49865102
Compound Name: PD-0325901
Targets: MAP2K1
MoA: MEK inhibitor
SMILES: OC[C@@H](O)CONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1406 BRD-K49865102 U2OS 1.11 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.19
29868 BRD-K49865102 A375 10 uM 6 h 0.0 0.0 0.0 0.39 1.39 2.17
30071 BRD-K49865102 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33044 BRD-K49865102 SKB 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
34375 BRD-K49865102 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36279 BRD-K49865102 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36829 BRD-K49865102 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92303 BRD-K49865102 MDAMB231 3.33 uM 3 h 0.0 0.0 0.0 0.27 0.97 0.34
92385 BRD-K49865102 SKBR3 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92458 BRD-K49865102 BT20 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92525 BRD-K49865102 HME1 0.04 uM 24 h 0.23 0.96 0.08 0.34 1.19 1.03
92605 BRD-K49865102 HS578T 0.12 uM 3 h 0.0 0.0 0.0 -0.28 -0.94 0.37
92659 BRD-K49865102 LNCAP 0.12 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
92726 BRD-K49865102 MCF10A 0.12 uM 3 h 0.23 0.98 0.09 -0.24 -0.81 0.13
93671 BRD-K49865102 ASC 10 uM 24 h 0.28 1.15 0.32 0.16 0.57 0.0
93736 BRD-K49865102 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93810 BRD-K49865102 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93861 BRD-K49865102 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
93943 BRD-K49865102 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94001 BRD-K49865102 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
94124 BRD-K49865102 NEU 10 uM 24 h -0.23 -0.96 0.09 0.26 0.91 0.23
94204 BRD-K49865102 PC3 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94805 BRD-K49865102 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
94909 BRD-K49865102 JURKAT 3.33 uM 24 h 0.25 1.05 0.18 0.0 0.0 0.0
95062 BRD-K49865102 NPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95185 BRD-K49865102 SHSY5Y 10 uM 24 h 0.24 1.01 0.11 0.0 0.0 0.0
95244 BRD-K49865102 SKL 1.11 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
95363 BRD-K49865102 MCF??7.00 0.12 uM 48 h -0.23 -0.94 0.08 -0.23 -0.78 0.09
97312 BRD-K49865102 HAP1 3.33 uM 24 h 0.26 1.08 0.21 0.3 1.07 0.61
125530 BRD-K49865102 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
133434 BRD-K49865102 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
133643 BRD-K49865102 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).