CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04150
Pert ID:	BRD-K99545815
Compound Name:	PF-562271
Targets:	PTK2\|PTK2B
MoA:	focal adhesion kinase inhibitor
SMILES:	CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33591	BRD-K99545815	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34225	BRD-K99545815	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34727	BRD-K99545815	HCC515	10 uM	6 h	0.0	0.0	0.0	0.27	0.97	0.34
35005	BRD-K99545815	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
36396	BRD-K99545815	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36696	BRD-K99545815	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91565	BRD-K99545815	BT20	10 uM	6 h	0.0	0.0	0.0	0.26	0.93	0.28
91703	BRD-K99545815	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92495	BRD-K99545815	HA1E	1.11 uM	24 h	-0.29	-1.23	0.62	0.0	0.0	0.0
92529	BRD-K99545815	HME1	3.33 uM	24 h	0.0	0.0	0.0	0.23	0.8	0.08
92578	BRD-K99545815	HS578T	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92693	BRD-K99545815	LNCAP	1.11 uM	3 h	0.0	0.0	0.0	-0.42	-1.43	15.35
92713	BRD-K99545815	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92802	BRD-K99545815	PC3	0.37 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
92825	BRD-K99545815	SKBR3	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128174	BRD-K99545815	HEK293	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128270	BRD-K99545815	MCF??7.00	3.33 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0
135783	BRD-K99545815	A549	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135913	BRD-K99545815	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135953	BRD-K99545815	HT29	2.22 uM	24 h	0.22	0.93	0.05	0.0	0.0	0.0
136003	BRD-K99545815	JURKAT	2.22 uM	24 h	-0.22	-0.91	0.06	0.0	0.0	0.0
136098	BRD-K99545815	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136149	BRD-K99545815	YAPC	2.22 uM	24 h	-0.29	-1.19	0.53	0.0	0.0	0.0

Summary